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Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer()

Non–small cell lung cancer (NSCLC) patients have very low survival rates because the current therapeutic strategies are not fully effective. Although EGFR tyrosine kinase inhibitors are effective for NSCLC patients harboring EGFR mutations, patients invariably develop resistance to these agents. Alt...

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Pubblicato in:Neoplasia
Autori principali: Bora-Singhal, Namrata, Perumal, Deepak, Nguyen, Jonathan, Chellappan, Srikumar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547412/
https://ncbi.nlm.nih.gov/pubmed/26297432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.07.001
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