Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor

The oncogenic E5 protein from bovine papillomavirus is a short (44 amino acids long) integral membrane protein that forms homodimers. It activates platelet-derived growth factor receptor (PDGFR) β in a ligand-independent manner by transmembrane helix-helix interactions. The nature of this recognitio...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Windisch, Dirk, Ziegler, Colin, Grage, Stephan L., Bürck, Jochen, Zeitler, Marcel, Gor’kov, Peter L., Ulrich, Anne S.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2015
Assuntos:
Membranes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547410/
https://ncbi.nlm.nih.gov/pubmed/26287626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.07.022
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