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Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis
Despite their broad anti-infective utility, the biosynthesis of the paradigm carbapenem antibiotic, thienamycin, remains largely unknown. Apart from the first two steps shared with a simple carbapenem, the pathway sharply diverges to the more structurally complex members of this class of β-lactam an...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547291/ https://ncbi.nlm.nih.gov/pubmed/26240322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508615112 |
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