Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation

Pathologic ocular angiogenesis is a leading cause of blindness, influenced by both dysregulated lipid metabolism and inflammation. Retinoic-acid-receptor–related orphan receptor alpha (RORα) is a lipid-sensing nuclear receptor with diverse biologic function including regulation of lipid metabolism a...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sun, Ye, Liu, Chi-Hsiu, SanGiovanni, John Paul, Evans, Lucy P., Tian, Katherine T., Zhang, Bing, Stahl, Andreas, Pu, William T., Kamenecka, Theodore M., Solt, Laura A., Chen, Jing
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547221/
https://ncbi.nlm.nih.gov/pubmed/26243880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504387112
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