Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures

A balance of van der Waals, electrostatic, and hydrophobic forces drive the folding and packing of protein side chains. Although such interactions between residues are often approximated as being pairwise additive, in reality, higher-order many-body contributions that depend on environment drive hyd...

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Bibliographic Details
Published in:Biophys J
Main Authors: LuCore, Stephen D., Litman, Jacob M., Powers, Kyle T., Gao, Shibo, Lynn, Ava M., Tollefson, William T.A., Fenn, Timothy D., Washington, M. Todd, Schnieders, Michael J.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547145/
https://ncbi.nlm.nih.gov/pubmed/26287633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.062
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