Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.

In vitro site-directed mutagenesis was used to replace individually the three known autophosphorylation sites of the epidermal growth factor (EGF)-receptor (i.e. Tyr1173, Tyr1148 and Tyr1068) by phenylalanine, a residue which cannot serve as a phosphate acceptor site. In another mutant, Tyr1173 was...

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Bibliographic Details
Main Authors: Honegger, A, Dull, T J, Bellot, F, Van Obberghen, E, Szapary, D, Schmidt, A, Ullrich, A, Schlessinger, J
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC454691/
https://ncbi.nlm.nih.gov/pubmed/3263271
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