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B-lymphocyte Specific loss of Ric-8A Results in a G(α) Protein Deficit and Severe Humoral Immunodeficiency
Resistance to inhibitors of cholinesterase 8A (Ric-8A) is a highly evolutionarily conserved cytosolic protein initially identified in C. elegans, where it was assigned a regulatory role in asymmetric cell divisions. It functions as a guanine nucleotide exchange factor for Gα(i), Gα(q), and Gα(12/13)...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4546893/ https://ncbi.nlm.nih.gov/pubmed/26232433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500523 |
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