Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1(cpk) Mouse

We have previously mapped the interval on Chromosome 4 for a major polycystic kidney disease modifier (Mpkd) of the B6(Cg)-Cys1 (cpk)/J mouse model of recessive polycystic kidney disease (PKD). Informatic analyses predicted that this interval contains at least three individual renal cystic disease s...

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Udgivet i:PLoS One
Main Authors: Mrug, Michal, Zhou, Juling, Yang, Chaozhe, Aronow, Bruce J., Cui, Xiangqin, Schoeb, Trenton R., Siegal, Gene P., Yoder, Bradley K, Guay-Woodford, Lisa M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546649/
https://ncbi.nlm.nih.gov/pubmed/26295839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135678
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