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Neurochemical metabolomics reveals disruption to sphingolipid metabolism following chronic haloperidol administration

Haloperidol is an effective antipsychotic drug for treatment of schizophrenia, but prolonged use can lead to debilitating side effects. To better understand the effects of long-term administration, we measured global metabolic changes in mouse brain following 3 mg/kg/day haloperidol for 28 days. The...

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Veröffentlicht in:J Neuroimmune Pharmacol
Hauptverfasser: McClay, Joseph L., Vunck, Sarah A., Batman, Angela M., Crowley, James J., Vann, Robert E., Beardsley, Patrick M., van den Oord, Edwin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546545/
https://ncbi.nlm.nih.gov/pubmed/25850894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-015-9605-1
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