Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration

BACKGROUND: Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge for mental illness. Sphingolipids play a role in glycaemic balance and insulin resistance. Endoplasmic reticulum (ER) stress contri...

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Bibliographic Details
Published in:J Biomed Sci
Main Authors: Weston-Green, Katrina, Babic, Ilijana, de Santis, Michael, Pan, Bo, Montgomery, Magdalene K., Mitchell, Todd, Huang, Xu-Feng, Nealon, Jessica
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932814/
https://ncbi.nlm.nih.gov/pubmed/29720183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-018-0437-1
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