Cargando...
Pin1-induced proline isomerization in cytosolic p53 mediates BAX activation and apoptosis
The cytosolic fraction of the tumor suppressor p53 activates the apoptotic effector protein BAX to trigger apoptosis. Here we report that p53 activates BAX through a mechanism different from that associated with activation by BH3 only proteins (BIM and BID). We observed that cis-trans isomerization...
Gardado en:
| Publicado en: | Mol Cell |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4546541/ https://ncbi.nlm.nih.gov/pubmed/26236013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.06.029 |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|