In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation

BACKGROUND: Inflammatory cytokines such as interleukin-1 beta (IL-1β) contribute to the progression of intervertebral disc degeneration. Previously we demonstrated, in vitro, that by delivering interleukin-1 receptor antagonist (IL-1ra) from poly(lactic co-glycolic acid) (PLGA) microspheres, we coul...

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Detalhes bibliográficos
Publicado no:J Exp Orthop
Main Authors: Gorth, Deborah J, Martin, John T, Dodge, George R, Elliott, Dawn M, Malhotra, Neil R, Mauck, Robert L, Smith, Lachlan J
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545798/
https://ncbi.nlm.nih.gov/pubmed/26914760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40634-014-0015-8
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