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The role of basic amino acid surface clusters on the collagenase activity of cathepsin K
Cathepsin K is a highly potent collagenase in osteoclasts and responsible for bone degradation. We have previously demonstrated that its unique collagenolytic activity is modulated by glycosaminoglycans that form high molecular complexes with the protease. However, mutational analysis of a specific...
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| 出版年: | Biochemistry |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4545644/ https://ncbi.nlm.nih.gov/pubmed/24088021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401051j |
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