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The role of basic amino acid surface clusters on the collagenase activity of cathepsin K
Cathepsin K is a highly potent collagenase in osteoclasts and responsible for bone degradation. We have previously demonstrated that its unique collagenolytic activity is modulated by glycosaminoglycans that form high molecular complexes with the protease. However, mutational analysis of a specific...
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| Publié dans: | Biochemistry |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4545644/ https://ncbi.nlm.nih.gov/pubmed/24088021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401051j |
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