Tet1 is a tumor suppressor of hematopoietic malignancy

The TET methylcytosine dioxygenase 1 (TET1) enzyme is an important regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. Decreased expression of TET proteins and loss of 5hmC in many tumors suggests a critical role for the maintenance of this epigenetic modification. Here we show that...

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Publicado no:Nat Immunol
Main Authors: Cimmino, Luisa, Dawlaty, Meelad M., Ndiaye-Lobry, Delphine, Yap, Yoon Sing, Bakogianni, Sofia, Yu, Yiting, Bhattacharyya, Sanchari, Shaknovich, Rita, Geng, Huimin, Lobry, Camille, Mullenders, Jasper, King, Bryan, Trimarchi, Thomas, Aranda-Orgilles, Beatriz, Liu, Cynthia, Shen, Steven, Verma, Amit K., Jaenisch, Rudolf, Aifantis, Iannis
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545281/
https://ncbi.nlm.nih.gov/pubmed/25867473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3148
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