Triple-strand-forming methylphosphonate oligodeoxynucleotides targeted to mRNA efficiently block protein synthesis.

Antisense oligonucleotides are ordinarily targeted to mRNA by double-stranded (Watson-Crick) base recognition but are seldom targeted by triple-stranded recognition. We report that certain all-purine methylphosphonate oligodeoxyribonucleotides (MPOs) form stable triple-stranded complexes with comple...

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Autors principals: Reynolds, M A, Arnold, L J, Almazan, M T, Beck, T A, Hogrefe, R I, Metzler, M D, Stoughton, S R, Tseng, B Y, Trapane, T L, Ts'o, P O
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC45452/
https://ncbi.nlm.nih.gov/pubmed/7528921
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