Triple-strand-forming methylphosphonate oligodeoxynucleotides targeted to mRNA efficiently block protein synthesis.

Antisense oligonucleotides are ordinarily targeted to mRNA by double-stranded (Watson-Crick) base recognition but are seldom targeted by triple-stranded recognition. We report that certain all-purine methylphosphonate oligodeoxyribonucleotides (MPOs) form stable triple-stranded complexes with comple...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Reynolds, M A, Arnold, L J, Almazan, M T, Beck, T A, Hogrefe, R I, Metzler, M D, Stoughton, S R, Tseng, B Y, Trapane, T L, Ts'o, P O
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45452/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7528921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.12433
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