Synergistic antiviral activities of oligonucleoside methylphosphonates complementary to herpes simplex virus type 1 immediate-early mRNAs 4, 5, and 1.

An oligonucleoside methylphosphonate (ONMP) complementary to the splice acceptor site of immediate-early (IE) pre-mRNAs 4 and 5 (IE4,5SA) inhibits herpes simplex virus type 1 (HSV-1) growth in vitro and in infected animals. The antiviral effect appears to be due to inhibition of IE pre-mRNA 4 and 5...

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Bibliographic Details
Main Authors: Kulka, M, Smith, C C, Levis, J, Fishelevich, R, Hunter, J C, Cushman, C D, Miller, P S, Ts'o, P O, Aurelian, L
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC284524/
https://ncbi.nlm.nih.gov/pubmed/8031030
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