Synergistic antiviral activities of oligonucleoside methylphosphonates complementary to herpes simplex virus type 1 immediate-early mRNAs 4, 5, and 1.

An oligonucleoside methylphosphonate (ONMP) complementary to the splice acceptor site of immediate-early (IE) pre-mRNAs 4 and 5 (IE4,5SA) inhibits herpes simplex virus type 1 (HSV-1) growth in vitro and in infected animals. The antiviral effect appears to be due to inhibition of IE pre-mRNA 4 and 5...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Kulka, M, Smith, C C, Levis, J, Fishelevich, R, Hunter, J C, Cushman, C D, Miller, P S, Ts'o, P O, Aurelian, L
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8031030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.4.675
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