Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.

The rat neu gene, which encodes a receptor-like protein homologous to the epidermal growth factor receptor, is frequently activated by a point mutation altering a valine residue to a glutamic acid residue in its predicted transmembrane domain. Additional point mutations have been constructed in a no...

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Bibliographic Details
Published in:EMBO J
Main Authors: Bargmann, C I, Weinberg, R A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1988
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454481/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2901345/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb03044.x
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