HPLC Measurement of the DNA Oxidation Biomarker, 8-oxo-7,8-dihydro-2’-deoxyguanosine, in Cultured Cells and Animal Tissues

Oxidative stress is associated with many physiological and pathological processes, as well as xenobiotic metabolism, leading to the oxidation of biomacromolecules, including DNA. Therefore, efficient detection of DNA oxidation is important for a variety of research disciplines, including medicine an...

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Udgivet i:J Vis Exp
Main Authors: Chepelev, Nikolai L., Kennedy, Dean A., Gagné, Remi, White, Taryn, Long, Alexandra S., Yauk, Carole L., White, Paul A.
Format: Artigo
Sprog:Inglês
Udgivet: MyJove Corporation 2015
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544582/
https://ncbi.nlm.nih.gov/pubmed/26273842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/52697
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