Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2(b) Haplotype

PURPOSE: Experimental autoimmune uveitis (EAU) induced in mice using the retinal antigen interphotoreceptor retinoid binding protein (IRBP) is an animal model for posterior uveitis in humans. However, EAU induced by native IRBP protein or its widely used epitope amino acid residues 1 to 20 of human...

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Detalles Bibliográficos
Publicado en:Invest Ophthalmol Vis Sci
Main Authors: Mattapallil, Mary J., Silver, Phyllis B., Cortes, Lizette M., St. Leger, Anthony J., Jittayasothorn, Yingyos, Kielczewski, Jennifer L., Moon, James J., Chan, Chi-Chao, Caspi, Rachel R.
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2015
Assuntos:
Immunology and Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544201/
https://ncbi.nlm.nih.gov/pubmed/26284549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17280
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