Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2(b) Haplotype

PURPOSE: Experimental autoimmune uveitis (EAU) induced in mice using the retinal antigen interphotoreceptor retinoid binding protein (IRBP) is an animal model for posterior uveitis in humans. However, EAU induced by native IRBP protein or its widely used epitope amino acid residues 1 to 20 of human...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Mattapallil, Mary J., Silver, Phyllis B., Cortes, Lizette M., St. Leger, Anthony J., Jittayasothorn, Yingyos, Kielczewski, Jennifer L., Moon, James J., Chan, Chi-Chao, Caspi, Rachel R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2015
Témata:
Immunology and Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544201/
https://ncbi.nlm.nih.gov/pubmed/26284549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17280
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