IL-15 Superagonist–Mediated Immunotoxicity: Role of NK Cells and IFN-γ

IL-15 is currently undergoing clinical trials to assess its efficacy for treatment of advanced cancers. The combination of IL-15 with soluble IL-15Rα generates a complex termed IL-15 superagonist (IL-15 SA) that possesses greater biological activity than IL-15 alone. IL-15 SA is considered an attrac...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Guo, Yin, Luan, Liming, Rabacal, Whitney, Bohannon, Julia K., Fensterheim, Benjamin A., Hernandez, Antonio, Sherwood, Edward R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2015
Schlagworte:
Innate Immunity and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543906/
https://ncbi.nlm.nih.gov/pubmed/26216888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500300
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