Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis

AIMS: Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are powerful regulators of gene expression and thus might mediate this process. METHODS AND RESULTS: OPN and miR-21 were significantly inc...

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Veröffentlicht in:Eur Heart J
Hauptverfasser: Lorenzen, Johan M., Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K., Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A., Weidemann, Frank, Müller, Oliver J., Haller, Hermann, Thum, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Basic Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543785/
https://ncbi.nlm.nih.gov/pubmed/25898844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv109
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