Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis

AIMS: Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are powerful regulators of gene expression and thus might mediate this process. METHODS AND RESULTS: OPN and miR-21 were significantly inc...

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Detalhes bibliográficos
Publicado no:Eur Heart J
Main Authors: Lorenzen, Johan M., Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K., Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A., Weidemann, Frank, Müller, Oliver J., Haller, Hermann, Thum, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543785/
https://ncbi.nlm.nih.gov/pubmed/25898844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv109
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