The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells

Re-activation of androgen receptor (AR) activity is the main driver for development of castration-resistant prostate cancer. We previously reported that the ubiquitin ligase Siah2 enhanced AR transcriptional activity and prostate cancer cell growth. Among the genes we found to be regulated by Siah2...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Fan, Lingling, Peng, Guihong, Hussain, Arif, Fazli, Ladan, Guns, Emma, Gleave, Martin, Qi, Jianfei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543648/
https://ncbi.nlm.nih.gov/pubmed/26160177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662155
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