Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism

BACKGROUND AND PURPOSE: Few neuropharmacological model systems use human neurons. Moreover, available test systems rarely reflect functional roles of co-cultured glial cells. There is no human in vitro counterpart of the widely used 1-methyl-4-phenyl-tetrahydropyridine (MPTP) mouse model of Parkinso...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Efremova, Liudmila, Schildknecht, Stefan, Adam, Martina, Pape, Regina, Gutbier, Simon, Hanf, Benjamin, Bürkle, Alexander, Leist, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543617/
https://ncbi.nlm.nih.gov/pubmed/25989025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13193
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