Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants

While the etiology of non-familial Parkinson’s disease (PD) remains unclear, there is evidence that increased levels of tissue iron may be a contributing factor. Moreover, exposure to some environmental toxicants is considered an additional risk factor. Therefore, brain-targeted iron chelators are o...

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Vydáno v:Arch Toxicol
Hlavní autoři: Gutbier, Simon, Kyriakou, Sotiris, Schildknecht, Stefan, Ückert, Anna-Katharina, Brüll, Markus, Lewis, Frank, Dickens, David, Pearson, Liam, Elson, Joanna L., Michel, Sylvia, Hubscher-Bruder, Véronique, Brandel, Jeremy, Tetard, David, Leist, Marcel, Pienaar, Ilse S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2020
Témata:
Molecular Toxicology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415766/
https://ncbi.nlm.nih.gov/pubmed/32607613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02826-y
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