Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite

Minocycline prevents oxidative protein modifications and damage in disease models associated with inflammatory glial activation and oxidative stress. Although the drug has been assumed to act by preventing the up-regulation of proinflammatory enzymes, we probed here its direct chemical interaction w...

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Main Authors: Schildknecht, Stefan, Pape, Regina, Müller, Nathalie, Robotta, Marta, Marquardt, Andreas, Bürkle, Alexander, Drescher, Malte, Leist, Marcel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037611/
https://ncbi.nlm.nih.gov/pubmed/21081502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169565
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