Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production versus consumption, may be involved in the pathogenesis of different diseases. The only known enzymes solely dedicated to ROS generation are nicotinamide adenine dinucleotide phosphate (NADPH) oxidases with their c...

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Publicat a:Antioxid Redox Signal
Autors principals: Altenhöfer, Sebastian, Radermacher, Kim A., Kleikers, Pamela W.M., Wingler, Kirstin, Schmidt, Harald H.H.W.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2015
Matèries:
Forum Review Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543484/
https://ncbi.nlm.nih.gov/pubmed/24383718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5814
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