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Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production versus consumption, may be involved in the pathogenesis of different diseases. The only known enzymes solely dedicated to ROS generation are nicotinamide adenine dinucleotide phosphate (NADPH) oxidases with their c...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Altenhöfer, Sebastian, Radermacher, Kim A., Kleikers, Pamela W.M., Wingler, Kirstin, Schmidt, Harald H.H.W.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543484/
https://ncbi.nlm.nih.gov/pubmed/24383718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5814
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