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Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production versus consumption, may be involved in the pathogenesis of different diseases. The only known enzymes solely dedicated to ROS generation are nicotinamide adenine dinucleotide phosphate (NADPH) oxidases with their c...

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Pubblicato in:Antioxid Redox Signal
Autori principali: Altenhöfer, Sebastian, Radermacher, Kim A., Kleikers, Pamela W.M., Wingler, Kirstin, Schmidt, Harald H.H.W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543484/
https://ncbi.nlm.nih.gov/pubmed/24383718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5814
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