Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor

Non-small cell lung cancers (NSCLCs) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent events in NSCLC, such as mutations in PTEN, EGFR, KRAS, and ALK, are only detected in, at most, 30% of patients. Thus, many unidentified low-penetrant events are causing a signi...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Dorr, Casey, Janik, Callie, Weg, Madison, Been, Raha A., Bader, Justin, Kang, Ryan, Ng, Brandon, Foran, Lindsey, Landman, Sean R., O’Sullivan, M. Gerard, Steinbach, Michael, Sarver, Aaron L., Silverstein, Kevin A. T., Largaespada, David A., Starr, Timothy K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543426/
https://ncbi.nlm.nih.gov/pubmed/25995385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0674-T
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