The multicopy appearance of a large inverted duplication and the sequence at the inversion joint suggest a new model for gene amplification.

The amplified DNA of HC50474, a Chinese hamster fibroblast cell line selected in three steps for high resistance to coformycin, consists chiefly of 150 copies of a large inverted duplication including the adenylate deaminase gene. Most if not all of these units are more than 2 x 120 kb long. The inv...

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Pubblicato in:	EMBO J
Autori principali:	Hyrien, O, Debatisse, M, Buttin, G, de Saint Vincent, B R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454335/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3366118/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb02828.x
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