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Paradigms lost—an emerging role for over-expression of tight junction adhesion proteins in cancer pathogenesis

Tight junctions (TJ) are multi-protein complexes located at the apicalmost tip of the lateral membrane in polarised epithelial and endothelial cells. Their principal function is in mediating intercellular adhesion and polarity. Accordingly, it has long been a paradigm that loss of TJ proteins and co...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Leech, Astrid O., Cruz, Rodrigo G.B., Hill, Arnold D.K., Hopkins, Ann M.
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543333/
https://ncbi.nlm.nih.gov/pubmed/26366401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2305-5839.2015.08.01
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