A T-cell–directed chimeric antigen receptor for the selective treatment of T-cell malignancies

Options for targeted therapy of T-cell malignancies remain scarce. Recent clinical trials demonstrated that chimeric antigen receptors (CARs) can effectively redirect T lymphocytes to eradicate lymphoid malignancies of B-cell origin. However, T-lineage neoplasms remain a more challenging task for CA...

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Bibliographic Details
Published in:Blood
Main Authors: Mamonkin, Maksim, Rouce, Rayne H., Tashiro, Haruko, Brenner, Malcolm K.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543231/
https://ncbi.nlm.nih.gov/pubmed/26056165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-629527
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