Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel

Diffuse congenital hyperinsulinism in infancy (CHI-D) arises from mutations inactivating the K(ATP) channel; however, the phenotype is difficult to explain from electrophysiology alone. Here we studied wider abnormalities in the β-cell and other pancreatic lineages. Islets were disorganized in CHI-D...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Salisbury, Rachel J., Han, Bing, Jennings, Rachel E., Berry, Andrew A., Stevens, Adam, Mohamed, Zainab, Sugden, Sarah A., De Krijger, Ronald, Cross, Sarah E., Johnson, Paul P.V., Newbould, Melanie, Cosgrove, Karen E., Hanley, Karen Piper, Banerjee, Indraneel, Dunne, Mark J., Hanley, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542438/
https://ncbi.nlm.nih.gov/pubmed/25931474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1202
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