Atypical Forms of Congenital Hyperinsulinism in Infancy Are Associated With Mosaic Patterns of Immature Islet Cells

OBJECTIVES: We aimed to characterize mosaic populations of pancreatic islet cells from patients with atypical congenital hyperinsulinism in infancy (CHI-A) and the expression profile of NKX2.2, a key transcription factor expressed in β-cells but suppressed in δ-cells in the mature pancreas. PATIENTS...

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Veröffentlicht in:J Clin Endocrinol Metab
Hauptverfasser: Han, Bing, Mohamed, Zainab, Estebanez, Maria Salomon, Craigie, Ross J., Newbould, Melanie, Cheesman, Edmund, Padidela, Raja, Skae, Mars, Johnson, Matthew, Flanagan, Sarah, Ellard, Sian, Cosgrove, Karen E., Banerjee, Indraneel, Dunne, Mark J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2017
Schlagworte:
Clinical Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587070/
https://ncbi.nlm.nih.gov/pubmed/28605545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-00158
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