The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interfer...

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Publicado en:Cell Rep
Main Authors: Mannion, Niamh M., Greenwood, Sam M., Young, Robert, Cox, Sarah, Brindle, James, Read, David, Nellåker, Christoffer, Vesely, Cornelia, Ponting, Chris P., McLaughlin, Paul J., Jantsch, Michael F., Dorin, Julia, Adams, Ian R., Scadden, A.D.J., Öhman, Marie, Keegan, Liam P., O’Connell, Mary A.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542304/
https://ncbi.nlm.nih.gov/pubmed/25456137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.041
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