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The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA
The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interfer...
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Publicado en: | Cell Rep |
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Main Authors: | , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado: |
Cell Press
2014
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Assuntos: | |
Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4542304/ https://ncbi.nlm.nih.gov/pubmed/25456137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.041 |
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