Amiloride Inhibits the Initiation of Coxsackievirus and Poliovirus RNA Replication by Inhibiting VPg Uridylylation

The mechanism of amiloride inhibition of Coxsackievirus B3 (CVB3) and poliovirus type 1 (PV1) RNA replication was investigated using membrane-associated RNA replication complexes. Amiloride was shown to inhibit viral RNA replication and VPgpUpU synthesis. However, the drug had no effect on polymeras...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Ogram, Sushma A., Boone, Christopher D., McKenna, Robert, Flanegan, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542153/
https://ncbi.nlm.nih.gov/pubmed/25058507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.06.025
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