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Amiloride Inhibits the Initiation of Coxsackievirus and Poliovirus RNA Replication by Inhibiting VPg Uridylylation
The mechanism of amiloride inhibition of Coxsackievirus B3 (CVB3) and poliovirus type 1 (PV1) RNA replication was investigated using membrane-associated RNA replication complexes. Amiloride was shown to inhibit viral RNA replication and VPgpUpU synthesis. However, the drug had no effect on polymeras...
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| izdano v: | Virology |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4542153/ https://ncbi.nlm.nih.gov/pubmed/25058507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.06.025 |
| Oznake: |
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