A fluorophore attached to nicotinic acetylcholine receptor βM2 detects productive binding of agonist to the αδ site

To study conformational transitions at the muscle nicotinic acetylcholine (ACh) receptor (nAChR), a rhodamine fluorophore was tethered to a Cys side chain introduced at the β19′ position in the M2 region of the nAChR expressed in Xenopus oocytes. This procedure led to only minor changes in receptor...

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Main Authors: Dahan, David S., Dibas, Mohammed I., Petersson, E. James, Auyeung, Vincent C., Chanda, Baron, Bezanilla, Francisco, Dougherty, Dennis A., Lester, Henry A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2004
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC454187/
https://ncbi.nlm.nih.gov/pubmed/15218096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0301885101
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