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Activity-based probes for the proteomic profiling of metalloproteases

Metalloproteases (MPs) are a large and diverse class of enzymes implicated in numerous physiological and pathological processes, including tissue remodeling, peptide hormone processing, and cancer. MPs are tightly regulated by multiple posttranslational mechanisms in vivo, hindering their functional...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Saghatelian, Alan, Jessani, Nadim, Joseph, Arul, Humphrey, Mark, Cravatt, Benjamin F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC454150/
https://ncbi.nlm.nih.gov/pubmed/15220480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402784101
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