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Activity-based probes for the proteomic profiling of metalloproteases

Metalloproteases (MPs) are a large and diverse class of enzymes implicated in numerous physiological and pathological processes, including tissue remodeling, peptide hormone processing, and cancer. MPs are tightly regulated by multiple posttranslational mechanisms in vivo, hindering their functional...

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Detalhes bibliográficos
Main Authors: Saghatelian, Alan, Jessani, Nadim, Joseph, Arul, Humphrey, Mark, Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC454150/
https://ncbi.nlm.nih.gov/pubmed/15220480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402784101
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