Ubiquitin–Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice

Protein aggregates containing ubiquitin (Ub) are commonly observed in neurodegenerative disorders, implicating the involvement of the ubiquitin proteasome system (UPS) in their pathogenesis. Here, we aimed to generate a mouse model for monitoring UPS function using a green fluorescent protein (GFP)-...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Liu, Yun, Li, Hongqiao, Sugiura, Yoshie, Han, Weiping, Gallardo, Gilbert, Khvotchev, Mikhail, Zhang, Yinan, Kavalali, Ege T., Südhof, Thomas C., Lin, Weichun
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540793/
https://ncbi.nlm.nih.gov/pubmed/26290230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5288-14.2015
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