Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand

Natural thymic T regulatory (tTreg) cells maintain tolerance to self-antigen. These cells are generated in the thymus, but how this generation occurs is still controversial. Furthermore, the contribution of thymus epithelial cells to this process is still unclear, especially in humans. Using an exce...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Nazzal, D, Gradolatto, A, Truffault, F, Bismuth, J, Berrih-Aknin, S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540205/
https://ncbi.nlm.nih.gov/pubmed/25210803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.377
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