Comparative Analysis of Thymic and Blood Treg in Myasthenia Gravis: Thymic Epithelial Cells Contribute to Thymic Immunoregulatory Defects

The thymus is involved in autoimmune Myasthenia gravis (MG) associated with anti-acetylcholine (AChR) antibodies. In MG, thymic regulatory T cells (Treg) are not efficiently suppressive, and conventional T cells (Tconv) are resistant to suppression. To better understand the specific role of the thym...

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Main Authors: Frédérique Truffault, Dani Nazzal, Julien Verdier, Angeline Gradolatto, Elie Fadel, Régine Roussin, Bruno Eymard, Rozen Le Panse, Sonia Berrih-Aknin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-05-01
Colecção:Frontiers in Immunology
Assuntos:
myasthenia gravis
thymus
PBMC
thymic epithelial cells
Treg
CD31
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.00782/full
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