UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

HSP90 inhibition represents a promising route to cancer therapy, taking advantage of cancer cell-inherent proteotoxic stress. The HSP90-inhibitor ganetespib showed benefit in advanced clinical trials. This raises the need to identify the molecular determinants of treatment response. We tested the ef...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Main Authors: Landmann, H, Proia, D A, He, S, Ogawa, L S, Kramer, F, Beißbarth, T, Grade, M, Gaedcke, J, Ghadimi, M, Moll, U, Dobbelstein, M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540199/
https://ncbi.nlm.nih.gov/pubmed/25210794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.378
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