Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma

Small cell lung carcinoma (SCLC) often features the up-regulation of the Sonic Hedgehog (Shh) pathway leading to activation of Gli transcription factors. SCLC cells secrete bombesin (BBS)-like neuropeptides (BLPs) that act as autocrine growth factors. Here, we show that SCLC tumour samples feature c...

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Udgivet i:Oncogene
Main Authors: Castellone, Maria Domenica, Laukkanen, Mikko O., Teramoto, Hidemi, Bellelli, Roberto, Alì, Greta, Fontanini, Gabriella, Santoro, Massimo, Gutkind, J Silvio
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539617/
https://ncbi.nlm.nih.gov/pubmed/24747971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.104
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