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The Biology of Proteostasis in Aging and Disease

Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is characterized by the appearance of nonnative protein aggregates in various tissues. Protein aggregation is routinely suppressed by the proteostasis network (PN), a collection of macromolecular machines that o...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Annu Rev Biochem
Prif Awduron: Labbadia, Johnathan, Morimoto, Richard I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539002/
https://ncbi.nlm.nih.gov/pubmed/25784053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-060614-033955
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