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Synthesis of 2′-Fluoro RNA by Syn5 RNA polymerase

The substitution of 2′-fluoro for 2′-hydroxyl moieties in RNA substantially improves the stability of RNA. RNA stability is a major issue in RNA research and applications involving RNA. We report that the RNA polymerase from the marine cyanophage Syn5 has an intrinsic low discrimination against the...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Zhu, Bin, Hernandez, Alfredo, Tan, Min, Wollenhaupt, Jan, Tabor, Stanley, Richardson, Charles C.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538805/
https://ncbi.nlm.nih.gov/pubmed/25897116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv367
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